![]() This in turn reduces the synthesis of thymidine and adenine nucleotides. It has been demonstrated that the methionine pool can be depleted by elevated homocysteine, and this is associated with an increase in the S-adenosylhomocysteine concentration. Research has identified the enzymes which metabolise homocysteine and have also identified the metabolic products of the process. The association between elevated plasma homocysteine and atherosclerosis is the subject of considerable research interest. ![]() Homocysteine is an effective scavenger of free radicals in vitro and has been shown to scavenge reactive oxygen species in cultured human cells in vitro. Oxidative stress causes damage to vascular endothelial cells and promotes the formation of foam cells, characteristic of the early stages of atherosclerosis. A further possible link between homocysteine and atherosclerosis is that elevated homocysteine concentrations are associated with increased oxidative stress. In addition, plasma homocysteine is markedly elevated in patients with renal disease, with those on dialysis having levels of 250-400 microM. ![]() Recent research has suggested that homocysteine may have a causal role in atherosclerosis. Its concentration in plasma is raised in renal disease and in those with vascular disease and so may contribute to their respective pathogenesis. This is remethylated back to methionine by methionine synthase. Homocysteine is a sulphur-containing amino acid produced in the liver by the conversion of methionine. Why not the Cd of Reasonable Doubt album download?Homocysteine, its metabolic products and cardiovascular disease. Todays free download Album in mp3 format of Jay-Z: Reasonable Doubt album is released on the Zip file. He is the CEO and President of the entertainment company Empire State of Mind Inc., a company he formed in December 1999. Jay-Z is a rapper, businessman, and entrepreneur and was born on Octoin Brooklyn, New York. Jay-Z, Reasonable Doubt Album Zip Download.
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